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Most k2 synthetic cannabinoids are agonists of the cannabinoid receptors. These synthetic analogs often have greater binding affinity and greater potency to the CB1 receptors. There are several synthetic cannabinoid families  which are classified by the creator of the substance (e.g. JWH stands for John W. Huffman), which can include several substances with different base structures such as classical cannabinoids and unrelated naphthoylindoles.

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Reported user negative effects include palpitations, paranoia, intense anxiety,

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ADB-BUTINACA (ADB-BINACA) is a new syntshetic cannabinoid that was first found in Europe in 2019.  

Although National Forensic Service (NFS) also identified it in authentic seizures

from early last year, it was unable to test biological samples due to the

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NFS finally established the method of detection in biological samples.

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